Friday, March 30, 2018

Anandi Gopal Joshi - Google Doodle - This year will probably see one for Janaki Ammal

It has been a while since I have written about JA. A lot has happened in that time. The most significant new thing is the Janaki Ammal Scholarships instituted by the John Innes Centre. I am very curious to know if students have joined a Ph.D. position availing this fellowship.  

Closer to home, today is the 153rd birthday of Anandi Gopal Joshi (one of the earliest Indian female physician). Google in its infinite wisdom decided to honor her with a doodle (see below). She has a degree certificate in one hand and appears to be wearing a stethoscope.  The image behind her is also split into two halves, one half is what could be her native country which had a scarcity of multi-storied houses during her time and the other half seems to be a townhouse in rural US of A. The trees also change accordingly.

For JA, they would need to have 3 continents, some sugar cane, brinjal and most definitely have karyotypes with various ploidy levels.

Anandi Gopal JoshiĆ¢€™s 153rd birthday

Now all I can hope for is that the folks at Google put two and two together and make a doodle for Janaki Ammal this year. Her birthday is on 4th of November and it will be 121 years. But then again it might take 32 more years. 

Wednesday, October 18, 2017

Getting creative with molecular biology

Creating something new using concepts you have learned leads to a better understanding of the subject.  Instead of simply remembering the ideas of somebody else, one can actually remember how one used those ideas to create something new. Yet, it is not easy to convince educators about the utility of using visual arts to teach science. A recent review titled "The Role of the Visual Arts in Enhancing the Learning Process" tries to make a case for visual arts in enhancing the learning process.

The class on "Flow of genetic information" that i am currently teaching got a chance to get creative this week. They were given 3 activities to do in the class.

Task 1: Compare DNA replication, Transcription & Translation and create an easy to understand diagram/table.

Task 2: Compare different information flow processes considering as many examples as you can think of

Task 3: Show the hierarchical organization of DNA

  • Use color chalk if needed.
  • Pay special attention to differences between prokaryotes & eukaryotes
Here are the end results:
Task 1

Task 2

Task 3

Thursday, August 24, 2017

Does the central dogma paper have hidden Masonic iconography?

A lot has been written about Freemasonry in recent times. One of the most prominent features of the iconography associated with free masons is the Eye of Providence. The traditional depiction of this involves a triangle or pyramid shape.

If you have read the paper Central Dogma of Molecular Biology by Francis Crick, you might have noticed that the paper is filled with figures that look like above screen grab. It is a triangle and has some circles. This would actually be a very smart way to sneak in Masonic iconography. Was Francis Crick a free mason? It is actually possible, as it has been argued that some of the most powerful and intellectually gifted people have been part of free masonry.

Monday, June 26, 2017

A beetle to be proud of

June is almost over. It has already started raining here in Bhopal. The weather is now at that pleasant optima when it's neither too hot nor too rainy. Wish it could stay like this forever. Humidity is another thing altogether. It is really a pleasure to go out walking in the campus.

You have the frogs making their calls in one place and the beetles roaming in another. See below picture of a beetle we managed to capture.

Wednesday, May 31, 2017

Nautapa - nine hottest days of the season

The end of May is generally the time for Nautapa, the nine hottest days of the season. The term originates from the Hindu astronomical calendar. Here is the sun early in the morning on the 5th day of Nautapa.

Wednesday, May 17, 2017

The Ponds at Georgetown - ducks

The Ponds at Georgetown or simply the ponds is a very pleasant place to live. Here is a picture of few ducks in the pond that is just beside the bus stop (bus #5).

If you zoom-in, at the far end of the pond you can see ducklings swimming. I counted 6 of them in total. While waiting for the bus, I could see a rodent (not sure if it was just a fat rat or some other) trying to swim into the flock and catch one of the ducklings. Probably that was breakfast.

One could imagine this is an advertisement for the place. With great public transportation proximity to the city as well as ypsilanti it is well situated. 

Comparative approaches to study the evolution of nucleotide diversity

Study of diversity at the nucleotide sequence level across the whole genome has provided a useful understanding of numerous processes. However, until recently these studies have been largely focussed within a species but using different populations. This is set to change with the explosion of datasets that are being generated in many species across the globe. We have made our tiny bit of contribution to the use of such an approach with a recent pre-print on bioRxiv "Genome-wide signatures of genetic variation within and between populations - a comparative perspective". 

Many other studies (Singhal et al., Van Doren et al., Ludo et al.) have shown this pattern of correlated landscapes of diversity and divergence. Some have even addressed other questions related to speciation rateshabitat preference as well as their impact on the diversity and divergence landscape. We are also seeing studies in other species groups such as primates and trees. Theoretically oriented groups have also started getting into the nitty gritty of things by trying to understand the patterns better and get into the processes driving them.

The figure-1 (b) from the bioRxiv paper is very interesting as I managed to sneak in the flags of both Germany and Sweden :). We had to cut it in our paper now published with a different title "Genome-wide patterns of variation in genetic diversity are shared among populations, species and higher-order taxa". Our paper even got featured on the Molecular Ecologist blog with a write-up by Arun Sethuraman.