Saturday, February 27, 2010

GANESH and Tuberculosis - Genomic Signature

Ganesh is a Hindu god who might have something to do with tuberculosis. No its not a divine or supernatural connection. Its more of a coincidental connection.

As we enter the post genomic era of creating synthetic organisms, the trend is to sign the genome with the name of the company or author of the genome in the genetic code. Assuming the various living organism that exist today are gods creations, it could be expected to have been signed by the gods. BRAMHA the god of creation would be expected to top the list. However, since the genetic code does not have a "B" it can be ruled out.

Lord Ganesh has signed his name in many genes, as a BlastP search will tell you. Dont believe me, take a look at the conserved protein from Mycobacterium tuberculosis T46 in NCBI.

>gi|289443584|ref|ZP_06433328.1| conserved hypothetical protein [Mycobacterium tuberculosis T46]
MFVDVGLLHSGANESHYAGEHAHGGADQLSRGPLLSGMFGTFPVAQTFHDAVGAAHAQQMRNLHAHRQAL
ITVGEKARHAATGSPTWTTATPLS

The genetic code seems to be more secular than most as it contains signatures from Allah as well. Take a look at another conserved protein from Pseudomonas. The greek goddess Demeter could also be located in Paenibacillus.
>gi|289627952|ref|ZP_06460906.1| enterobactin synthase subunit F [Pseudomonas syringae pv. aesculi str. NCPPB3681]
AASTSGAVINVLPMQVQVAPQATMAELAHGITAELKRLRKHQRYNAEQIQRDLGRIGDAEPLYGAVLNLK
LFDFELDLDGIAGVTHTLASGPVRDMEIALRFNPCGDVSLELLANAERYDDATLARHLRRLSLLLEQFGA
NPQLSCEAASPLDREDQALLAHVNDTAQPLTEDTLV

If you know any other secret messages that the gods encoded in the genome?